The Brown Norway opticospinal model of demyelination: does it mimic multiple sclerosis or neuromyelitis optica?

Autor: Collongues N; Laboratoire d'Imagerie et de Neurosciences Cognitives, UMR 7237 CNRS/UDS, Université de Strasbourg, Faculté de Médecine, 4 Rue Kirschleger, Strasbourg, France. nicolas.collongues@chru-Strasbourg.fr, Chanson JB, Blanc F, Steibel J, Lam CD, Shabbir A, Trifilieff E, Honnorat J, Pham-Dinh D, Ghandour MS, de Seze J
Jazyk: angličtina
Zdroj: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience [Int J Dev Neurosci] 2012 Oct; Vol. 30 (6), pp. 487-97. Date of Electronic Publication: 2012 May 24.
DOI: 10.1016/j.ijdevneu.2012.05.004
Abstrakt: Opticospinal demyelinating diseases in humans are mostly characterized by the opticospinal form of multiple sclerosis (MS) and neuromyelitis optica (NMO). Increasing attention has recently focused on astrocyte markers, aquaporin-4 (AQP4) and glial fibrillary acidic protein (GFAP) in these diseases. We induced opticospinal demyelination in Brown Norway rats with soluble recombinant rat myelin oligodendrocyte glycoprotein (1-116) and incomplete Freund's adjuvant. Clinical, MRI, neuropathological and immunological evaluations were performed, with a focus on AQP4 and GFAP. We confirmed the opticospinal phenotype, including extensive myelitis, but also showed the MRI-characterized involvement of the periventricular area. Expression levels of myelin, AQP4 and GFAP showed the early involvement of astrocytes before demyelination in the optic nerve. The overexpression of AQP4 was particularly pronounced in the spinal cord and was concomitant with demyelination and astrocyte apoptosis. The disability scores were correlated with demyelination and inflammation but not with AQP4/GFAP expression. No antibodies against the linear and conformational epitopes of AQP4 were detected. Whereas a NMO-like phenotype was observed in this model, the AQP4/GFAP expression during the disease process was more closely related to opticospinal MS than NMO. However, this model raises the question of a continuum between opticospinal MS and the seronegative NMO subtype.
(Copyright © 2012 ISDN. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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