Pattern recognition receptors in equine endotoxaemia and sepsis.
| Autor: | Werners AH; Anatomy, Physiology and Pharmacology Academic Programme, School of Veterinary Medicine, St George's University, True Blue, Grenada, West Indies., Bryant CE |
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| Jazyk: | angličtina |
| Zdroj: | Equine veterinary journal [Equine Vet J] 2012 Jul; Vol. 44 (4), pp. 490-8. Date of Electronic Publication: 2012 May 20. |
| DOI: | 10.1111/j.2042-3306.2012.00574.x |
| Abstrakt: | Pattern recognition receptors (PRRs) on host cells detect pathogens to activate innate immunity which, in turn, initiates inflammatory and adaptive immune responses. Successful activation of PRRs is, therefore, critical to controlling infections and driving pathogen-specific adaptive immunity, but overactivity of PRRs causes systemic inflammation, which is detrimental to the host. Here we review the PRR literature as it relates to horses and speculate on the role PRRs may play in sepsis and endotoxaemia. (© 2012 EVJ Ltd.) |
| Databáze: | MEDLINE |
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