| Autor: |
Boffetta P; Tisch Cancer Institute, Mount Sinai School of Medicine, NY, USA. paolo.boffetta@mssm.edu, Winn DM, Ioannidis JP, Thomas DC, Little J, Smith GD, Cogliano VJ, Hecht SS, Seminara D, Vineis P, Khoury MJ |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of epidemiology [Int J Epidemiol] 2012 Jun; Vol. 41 (3), pp. 686-704. Date of Electronic Publication: 2012 May 16. |
| DOI: |
10.1093/ije/dys010 |
| Abstrakt: |
We propose guidelines to evaluate the cumulative evidence of gene-environment (G × E) interactions in the causation of human cancer. Our approach has its roots in the HuGENet and IARC Monographs evaluation processes for genetic and environmental risk factors, respectively, and can be applied to common chronic diseases other than cancer. We first review issues of definitions of G × E interactions, discovery and modelling methods for G × E interactions, and issues in systematic reviews of evidence for G × E interactions, since these form the foundation for appraising the credibility of evidence in this contentious field. We then propose guidelines that include four steps: (i) score the strength of the evidence for main effects of the (a) environmental exposure and (b) genetic variant; (ii) establish a prior score category and decide on the pattern of interaction to be expected; (iii) score the strength of the evidence for interaction between the environmental exposure and the genetic variant; and (iv) examine the overall plausibility of interaction by combining the prior score and the strength of the evidence and interpret results. We finally apply the scheme to the interaction between NAT2 polymorphism and tobacco smoking in determining bladder cancer risk. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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