Efficacy of VBHOM to predict outcome following major lower limb amputation.

Autor:	Patterson AJ; MRIS Unit & University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK. andrew.patterson@addenbrookes.nhs.uk, Degnan AJ, Walsh SR, Eltayeb M, Scout EF, Clarke JM, Wilson YG, Tang TY
Jazyk:	angličtina
Zdroj:	Vascular and endovascular surgery [Vasc Endovascular Surg] 2012 Jul; Vol. 46 (5), pp. 369-73. Date of Electronic Publication: 2012 May 15.
DOI:	10.1177/1538574412445600
Abstrakt:	Purpose: This study tests an existing Vascular Biochemistry and Haematology Outcome Model (VBHOM) on independent data and presents further refinements to the model. Methods: Data from 306 patients who underwent lower limb amputation over a 4-year period were collated. Urea, creatinine, sodium, potassium, hemoglobin, white cell count, albumin, age, gender, mode-of-admission, and short-term mortality events were extracted from the database. This study tests an existing model and trains a new model for predicting mortality using forward stepwise logistic regression. Results: The existing model suggests a significant lack of fit (c-index = 0.665, P = .04). For the exception of gender and mode-of-admission, all predictor variables had significant univariate associations with short-term mortality (P < .05). The refined model included age, sodium, potassium, creatinine, and albumin and had good discriminatory power (c-index = 0.8, no evidence of lack of fit, P = .616). Conclusions: Our simplified model had good predictive ability and suggests redundancy in input variables used by the existing models.
Databáze:	MEDLINE
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