Effects of subclinical hypothyroidism treatment on psychiatric symptoms, muscular complaints, and quality of life.

Autor:	Reuters VS; School of Medicine, Universidade Federal do Rio de Janeiro, Brazil. vsreuters@hotmail.com, Almeida Cde P, Teixeira Pde F, Vigário Pdos S, Ferreira MM, Castro CL, Brasil MA, Costa AJ, Buescu A, Vaisman M
Jazyk:	angličtina
Zdroj:	Arquivos brasileiros de endocrinologia e metabologia [Arq Bras Endocrinol Metabol] 2012 Mar; Vol. 56 (2), pp. 128-36.
DOI:	10.1590/s0004-27302012000200006
Abstrakt:	Objectives: To evaluate the impact of subclinical hypothyroidism (sHT) treatment on health-related quality of life (QoL), psychiatric symptoms, clinical score, and muscle function. Materials and Methods: In this randomized double-blind study, patients were assigned either to treatment (n = 35) or placebo (n = 36). Clinical and psychiatric symptoms were assessed by the Zulewski, Hamilton and Beck scales. QoL was assessed by the SF-36 questionnaire. Assessments of quadriceps (QS) and inspiratory muscle (IS) strength were performed by a chair dynamometer and a manuvacuometer. Results: Treatment improved IS (+11.5 ± 17.2; p = 0.041), as did QoL domains "Pain" and "Role Physical" (+19.7 ± 15.2, 0.039 and +22.1 ± 47.5, p = 0.054; respectively). Clinical and psychiatric symptoms showed similar responses to both interventions. Conclusions: sHT treatment improved IS and physical aspects of QoL, despite no impact in other muscle parameters. Clinical score, psychiatric symptoms, and SF-36 domains, based on mental dimensions of QoL may be more susceptible to "placebo effect" in patients with sHT.
Databáze:	MEDLINE
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