Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis.

Autor: Suk KT; Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea., Kim DJ, Kim CH, Park SH, Cheong JY, Cho SW, Choi JY, Han KH, Sung HT, Hong SH, Kim DY, Yoon JH, Kim YS, Baik GH, Kim JB
Jazyk: angličtina
Zdroj: Clinical biochemistry [Clin Biochem] 2012 Sep; Vol. 45 (13-14), pp. 1075-80. Date of Electronic Publication: 2012 May 08.
DOI: 10.1016/j.clinbiochem.2012.04.031
Abstrakt: Objectives: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver.
Methods: Patients with chronic viral hepatitis (n=101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled.
Results: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (-3.13+0.017×MMP2-0.019×haptoglobin and -0.270+0.007×HA-0.018×haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p=0.03), MMP2 (0.72/0.63, p=0.04), HA (0.79/0.76, p=0.94), Apo-A1 (0.56/0.48, p=0.73), and predictive logit-model (0.81/0.78, p=0.68) showed higher diagnostic value in the HV sample.
Conclusions: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.
(Copyright © 2012 The Canadian Society of Clinical Chemists. All rights reserved.)
Databáze: MEDLINE
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