Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring.
| Autor: | Mohammed Iqbal AK; Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad, Karnataka 580003, India., Khan AY, Kalashetti MB, Belavagi NS, Gong YD, Khazi IA |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | European journal of medicinal chemistry [Eur J Med Chem] 2012 Jul; Vol. 53, pp. 308-15. Date of Electronic Publication: 2012 Apr 21. |
| DOI: | 10.1016/j.ejmech.2012.04.015 |
| Abstrakt: | Novel thiazolidinedione derivatives were synthesized by incorporating pharmacologically significant heterocycles viz, substituted thiazole, triazole, and oxadiazole moieties linked to the central phenyl ring via heteroatomlinkage with one/two carbon spacer as the structural analogs of Pioglitazone by employing multistep synthetic protocols. Structures of all the newly synthesized intermediates and target molecules were established by analytical and spectral data. These newly synthesized compounds were screened for their invivo hypoglycemic and hypolipidemic activities in male wistar rats. Some of the synthesized compounds demonstrated good activity. (Copyright © 2012 Elsevier Masson SAS. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect