Prevalence of autoantibodies in a group of hereditary angioedema patients.

Autor: Dortas Junior SD; Internal Medicine, Hospital Geral de Nova Iguaçu, Nova Iguaçu, RJ, Brazil. sdortasjr@gmail.com, Valle SO, Levy SA, Tortora RP, Abe AT, Pires GV, Papi JA, França AT
Jazyk: angličtina
Zdroj: Anais brasileiros de dermatologia [An Bras Dermatol] 2012 Mar-Apr; Vol. 87 (2), pp. 332-4.
DOI: 10.1590/s0365-05962012000200030
Abstrakt: Hereditary Angioedema is a dominantly inherited disease. Routine screening of autoantibodies (AAB) is not recommended for individuals with Hereditary Angioedema; however, prevalence of these antibodies in Hereditary Angioedema patients is not well documented. We aim to determine the prevalence of AAB so that individuals at risk of developing autoimmune diseases can be identified. Fifteen patients with Hereditary Angioedema attended at Clementino Fraga Filho University Hospital accepted to participate in this study. Prevalence of AAB was 40%. Our data indicate high prevalence of AAB in patients with Hereditary Angioedema. Large-scale studies should be considered to determine the significance of these AAB in the follow-up care of patients with Hereditary Angioedema.
Databáze: MEDLINE