| Autor: |
Nesterova AP, Nizamutdinov II, Koniukhov BV |
| Jazyk: |
ruština |
| Zdroj: |
Ontogenez [Ontogenez] 2012 Jan-Feb; Vol. 43 (1), pp. 60-5. |
| Abstrakt: |
Mutant gene wallhaarig (wa) was acting as a modifier of the mutant gene waved alopecia (wal), substantially increasing hair loss rate in mice, as was previously shown in our laboratory. The current paper is devoted to a study of mutant gene angora- Y(Fgf5(go-Y)), which had extended anagen stage of the first and second generations hair growth cycles in triple heterozygotes (Fgf5(go-Y)/Fgf5(go-Y) we/we wal/wal). First generation guard hair in triple homozygotes had their anagen stage 4 days longer than the same stage in double homozygotes (+/+ we/we wal/wal). Hair loss started at a catagen stage in double homozygotes, while it started in triple homozygotes at the end of the same stage or even in a telogen. Such mutant gene interaction in hair follicle morphogenesis led to a partial recovery of a body hair coat in triple homozygotes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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