| Autor: |
Liapina LA, Miasoedov NF, Andreeva LA, Obergan TIu, Shubina TA, Grigor'eva ME, Pastorova VE |
| Jazyk: |
ruština |
| Zdroj: |
Izvestiia Akademii nauk. Seriia biologicheskaia [Izv Akad Nauk Ser Biol] 2012 Jan-Feb (1), pp. 72-7. |
| Abstrakt: |
Heparin was bound to the arginine-containing peptide Arg-Pro-Gly-Pro with the molar ratio of heparin to the peptide 1:1. The complex compound showed antiplatelet, anticoagulative, and fibrin-depolymerization activities. In an in vivo study, in type 2 diabetes progression, a 5-fold intranasal administration of the compound restored both impaired insular and anticlotting functions in rats. Furthermore, blood fibrinolytic and anticoagulative activities increased. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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