| Autor: |
L'vov ND, Samoĭlovich EO, Tikhonchuk IA, Vanag AI, Lidak MIu, Chepaĭkina TA, Tsvetkov EN, Barinskiĭ IF |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy virusologii [Vopr Virusol] 1990 Jul-Aug; Vol. 35 (4), pp. 338-42. |
| Abstrakt: |
Chemical drugs and the Soviet interferon inducer larifan as well as their combinations were evaluated in genital herpes in male guinea pigs. Among the chemical drugs tested, the highest efficacy was observed with 2% phosphonoformic acid trisodiate ointment (its therapeutic effect 62%). The efficacy of 2% cycloguanosine ointment and 0.5% phosphonoacetic ointment did not exceed 43% and 36%, respectively. Topical and systemic use of the interferon inducer larifan produced a marked therapeutic effect (63%). Combined use of purophosphate and cycloguanosine analogues was more effective than the agents alone, yet the effect of the combinations being nothing more than additive. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
