| Autor: |
Evans M; KGK Synergize Inc., 255 Queens Avenue, Suite 1440, London, ON, Canada N6A 5R8., Reeves S, Robinson LE |
| Jazyk: |
angličtina |
| Zdroj: |
Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2012; Vol. 2012, pp. 973041. Date of Electronic Publication: 2012 Apr 05. |
| DOI: |
10.1155/2012/973041 |
| Abstrakt: |
Diverse and significant benefits against cold/flu symptoms and seasonal allergies have been observed with a dried fermentate (DF) derived from Saccharomyces cerevisiae (EpiCor) in multiple published randomized trials. To determine if DF may influence other immune conditions, two separate animal studies were conducted. Study 1 examined the ability of DF to prevent or reduce inflammation when given orally for 14 days to rats prior to receiving 1% carrageenan (localized inflammation model). DF significantly (P < 0.05) reduced swelling at all time points (1, 2, 3, 6, 12, and 24 hours) versus the control. Edema severity and PGE2 levels were reduced by approximately 50% and 25% (P < 0.05), respectively. Study 2 examined the ability of DF to treat established inflammation induced by type-2 collagen in mice over 4 weeks (autoimmune arthritis model). Significantly reduced arthritis scores, antibody response to type-2 collagen, and interferon-gamma levels were observed compared to controls (all parameters P < 0.05). DF favorably impacts multiple acute and potentially chronic immunologic inflammatory control mechanisms and should be further tested in clinical trials. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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