Neutrophil recruitment is inhibited by nicotinamide in experimental pleurisy in mice.

Autor: Ferreira RG; Laboratório de Inflamação e Dor - Instituto de Ciências Biológicas, UFMG, Brazil., Matsui TC, Godin AM, Gomides LF, Pereira-Silva PE, Duarte ID, Menezes GB, Coelho MM, Klein A
Jazyk: angličtina
Zdroj: European journal of pharmacology [Eur J Pharmacol] 2012 Jun 15; Vol. 685 (1-3), pp. 198-204. Date of Electronic Publication: 2012 Apr 20.
DOI: 10.1016/j.ejphar.2012.04.014
Abstrakt: Several emerging lines of evidence support an anti-inflammatory role for nicotinamide and other vitamin B components. However, the mechanisms underlying their activity remain unclear. In the present study, we investigated the ability of nicotinamide to inhibit both neutrophil recruitment in IL-8-, LTB(4)- or carrageenan-induced pleurisy in mice and the rolling and adherence of neutrophils. Nicotinamide inhibited IL-8-, LTB(4)- and carrageenan-induced neutrophil migration, KC production and carrageenan-induced neutrophil rolling and adherence. We propose that the effects of nicotinamide in inhibiting neutrophil recruitment in carrageenan-induced pleurisy may be due to the ability of nicotinamide to inhibit the action of IL-8 and LTB(4), decrease KC production, and inhibit early events that regulate leukocyte migration from blood vessels into tissue.
(Copyright © 2012 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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