Preload dependence of gated cardiac SPECT-derived ventricular volumes in hemodialysis patients.

Autor: Jimenez-Heffernan A; Department of Nuclear Medicine, Hospital Juan Ramon Jimenez, Huelva, Spain. ameliam.jimenez.sspa@juntadeandalucia.es, de Mora ES, Salgado C, Lopez-Martin J, Ramos C, Rodriguez-Gomez E, Tobaruela A
Jazyk: angličtina
Zdroj: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2012 Aug; Vol. 19 (4), pp. 743-51. Date of Electronic Publication: 2012 Apr 24.
DOI: 10.1007/s12350-012-9560-7
Abstrakt: Background: In hemodialysis (HD) patients, the intravascular volume expansion of the pre-HD state leads to a high preload. We aim to examine its effect on myocardial perfusion gated SPECT (MPGS)-derived left ventricular (LV) volumes.
Methods: The study comprised 50 end-stage renal disease (ESRD) patients on HD with normal 2-day stress/rest MPGS performed for kidney transplantation risk assessment. Patients (pts) comprised 23 men/27 women, with mean age of 59.4 ± 7.1 years. The time elapsed from the last HD session in hours was calculated on both days, and patients were classified according to whether it was higher (group A: 19 pts), lower (group B: 27 pts), or equal (group C: 4 pts) on the stress vs the rest day. End-diastolic, end-systolic volumes (EDV, ESV), and left ventricular ejection fraction (LVEF) were determined using QGS™ software. Transient ischemic dilation (TID) ratios were derived from the nongated images using QPS™ software.
Results: Volumes were significantly higher at stress in group A, at rest in group B, and similar in group C. TID ratios were significantly higher in group A vs groups B and C.
Conclusions: MPGS-derived ventricular volumes are preload dependent. The high preload of the pre-HD state may mimic ischemic TID if occurring on the stress day and create confusion if coinciding with the rest day.
Databáze: MEDLINE
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