| Autor: |
Makhonova LA, Maiakova SA, Kiselev AV, Gordina GA, Balakirev SA, Gavrilova IE, Moiseenko EI, Morozova OV |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy onkologii [Vopr Onkol] 1990; Vol. 36 (10), pp. 1196-200. |
| Abstrakt: |
Tolerability and efficacy of high-dose methotrexate was studied in 70 pediatric patients with lymphoblastic tumors (acute lymphoblastic leukemia and non-Hodgkin's lymphoma). Methotrexate was given by 24-hour infusion of 500-1000 mg/m2 (total dose-700-3000 mg) after remission had been achieved. An antidote--calcium folinate--was administered 24 hours postinfusion. Major adverse side-effects involved were stomatitis, hepatotoxicity and fever. Survival in the study group was higher than in controls. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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