| Autor: |
Cintra e Silva Dde O; University of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Electronic Microscopy, Brasília DF, 70919-970, Brazil., Estevanato LL, Simioni AR, Rodrigues MM, Lacava BM, Lacava ZG, Tedesco AC, Morais PC, Báo SN |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of biomedical nanotechnology [J Biomed Nanotechnol] 2012 Feb; Vol. 8 (1), pp. 182-9. |
| DOI: |
10.1166/jbn.2012.1370 |
| Abstrakt: |
This study reports on the successful use of magnetic albumin nanosphere (MAN), consisting of maghemite nanoparticles hosted by albumin-based nanosphere, to target different sites within the central nervous system (CNS). Ultrastructural analysis by transmission electron microscopy (TEM) of the material collected from the mice was performed in the time window of 30 minutes up to 30 days after administration. Evidence found that the administered MAN was initially internalized and transported by erythrocytes across the blood-brain-barrier and transferred to glial cells and neuropils before internalization by neurons, mainly in the cerebellum. We hypothesize that the efficiency of MAN in crossing the BBB with no pathological alterations is due to the synergistic effect of its two main components, the iron-based nanosized particles and the hosting albumin-based nanospheres. We found that the MAN in targeting the CNS represents an important step towards the design of nanosized materials for clinical and diagnostic applications. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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