Gamma knife radiosurgery in the treatment of tumor-related facial pain.

Autor:	Squire SE; Department of Radiation Oncology, Wake Forest University, Winston-Salem, NC, USA. sarahsquire@gmail.com, Chan MD, Furr RM, Lowell DA, Tatter SB, Ellis TL, Bourland JD, Deguzman AF, Munley MT, Ekstrand KE, Shaw EG, McMullen KP
Jazyk:	angličtina
Zdroj:	Stereotactic and functional neurosurgery [Stereotact Funct Neurosurg] 2012; Vol. 90 (3), pp. 145-50. Date of Electronic Publication: 2012 Apr 11.
DOI:	10.1159/000335873
Abstrakt:	Background: Intracranial neoplasms can cause pain similar to trigeminal neuralgia. Literature regarding radiosurgery for this is limited. We present a retrospective review of patients with tumor-related facial pain from benign lesions treated with gamma knife radiosurgery (GKRS) at Wake Forest University. Objectives: The primary objectives were to determine long-term pain relief and predictive factors for pain alleviation. Methods: We reviewed 515 patients treated with GKRS for benign meningioma, vestibular schwannoma or trigeminal schwannoma between August 1999 and August 2010. Twenty-one eligible patients had tumor-related facial pain prior to GKRS. The median marginal tumor dose was 12 Gy. Long-term pain relief data were obtained by chart review and telephone interview. Results: The median follow-up for symptom evaluation was 3.8 years. Seventeen of 21 patients (81%) experienced a Barrow Neurological Institute (BNI) score of I-III at 6 months following GKRS. Kaplan-Meier estimates of freedom from BNI IV-V relapse were 66% at 1 year and 53% at 2 years. No pain relapses occurred after 2 years. Conclusion: GKRS of benign lesions is a noninvasive option for patients with tumor-related facial pain. Pain relief is modest, with the majority of pain relapses occurring within 2 years and approximately one half of patients maintaining relief beyond 2 years. (Copyright © 2012 S. Karger AG, Basel.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu