Uveitis and common variable immunodeficiency: data from the DEF-I study and literature review.

Autor: Pasquet F; Department of Internal Medicine, Hôpital Croix-Rousse, Lyon, France., Kodjikian L, Mura F, Riviere S, Harroche J, Blanc AP, Chaix F, Oksenhendler E, Seve P
Jazyk: angličtina
Zdroj: Ocular immunology and inflammation [Ocul Immunol Inflamm] 2012 Jun; Vol. 20 (3), pp. 163-70. Date of Electronic Publication: 2012 Apr 17.
DOI: 10.3109/09273948.2012.674612
Abstrakt: Purpose: To examine the relation between uveitis and common variable immunodeficiency (CVID).
Methods: Retrospective analysis of patients included in the French DEFI cohort of adults with CVID and of patients identified by reviewing the literature.
Results: Four patients were identified in the DEFI study (frequency of uveitis: 1.6%). The course of uveitis was not changed in the patients who started intravenous immunoglobulins replacement therapy after CVID diagnosis. Ten cases of CVID-associated uveitis were listed in the literature. Overall, among the 14 patients, uveitis was always chronic, usually bilateral (n = 11) and granulomatous (n = 9). Seven patients presented with a "sarcoid-likeâ syndrome. Nine patients had granulomatous uveitis suggestive of ocular sarcoidosis. Five patients were treated with local corticosteroids, and 9 required systemic treatment (corticosteroids alone n = 5 and/or immunosuppressive agents n = 4).
Conclusions: CVID can be associated with uveitis. Since uveitis can reveal the immunodeficiency, CVID diagnosis should be considered at the time of uveitis diagnosis.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje