| Autor: |
Wang J; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China., Yuan Y, Xiong R, Zhang-Negrerie D, Du Y, Zhao K |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2012 May 04; Vol. 14 (9), pp. 2210-3. Date of Electronic Publication: 2012 Apr 12. |
| DOI: |
10.1021/ol300418h |
| Abstrakt: |
The reaction of phenyliodine bis(trifluoroacetate) (PIFA) with a series of anilides 1 (E = CO(2)Et) in CF(3)CH(2)OH was found to give 3-hydroxy-2-oxindole derivatives 2, while that with various anilides 1' (E = CON(R(4))Ar) afforded the C(2)-symmetric or unsymmetric spirooxindoles 3. These processes feature a metal-free oxidative C(sp(2))-C(sp(3)) bond formation, followed by oxidative hydroxylation or spirocyclization. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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