| Autor: |
Cary LH; Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute (AFRRI), Uniformed Services University, Bethesda, Maryland 20889-5603, USA., Ngudiankama BF, Salber RE, Ledney GD, Whitnall MH |
| Jazyk: |
angličtina |
| Zdroj: |
Radiation research [Radiat Res] 2012 May; Vol. 177 (5), pp. 663-75. Date of Electronic Publication: 2012 Apr 03. |
| DOI: |
10.1667/rr2783.1 |
| Abstrakt: |
The detonation of a nuclear weapon or a nuclear accident represent possible events with significant exposure to mixed neutron/γ-radiation fields. Although radiation countermeasures generally have been studied in subjects exposed to pure photons (γ or X rays), the mechanisms of injury of these low linear energy transfer (LET) radiations are different from those of high-LET radiation such as neutrons, and these differences may affect countermeasure efficacy. We compared 30-day survival in mice after varying doses of pure γ and mixed neutron/γ (mixed field) radiation (MF, Dn/Dt = 0.65), and also examined peripheral blood cells, bone marrow cell reconstitution, and cytokine expression. Mixed-field-irradiated mice displayed prolonged defects in T-cell populations compared to mice irradiated with pure γ photons. In mouse survival assays, the growth factor granulocyte colony-stimulating factor (G-CSF) was effective as a (post-irradiation) mitigator against both γ-photons and mixed-field radiation, while the thrombopoietin (TPO) mimetic ALXN4100TPO was effective only against γ irradiation. The results indicate that radiation countermeasures should be tested against radiation qualities appropriate for specific scenarios before inclusion in response plans. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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