| Autor: |
Skellern GG; Drug Metabolism Unit, Department of Pharmaceutical Chemistry, University of Strathclyde, Glasgow, Scotland., Stenlake JB, Williams WD, McLarty DG |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of clinical pharmacology [Br J Clin Pharmacol] 1974 Jun; Vol. 1 (3), pp. 265-9. |
| DOI: |
10.1111/j.1365-2125.1974.tb00248.x |
| Abstrakt: |
1 Carbimazole was administered to nine hyperthyroid patients, and blood samples were taken at various time intervals for analysis of carbimazole, and its metabolite methimazole.2 A technique was developed for the measurement of methimazole in serum using a High-Pressure Liquid Chromatograph, which could detect nanogram quantities of this metabolite.3 After a single oral dose, the patients' blood levels appeared to fall into two groups, either those with a maximum concentration of methimazole between 30 and 60 min, or those whose maximum was 2 to 3 hours.4 The results would suggest that there could be a correlation between the high level of methimazole in serum and the high thyroxine concentration found in some patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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