| Autor: |
Borland RG; Royal Air Force Institute of Aviation Medicine, Farnborough, Hampshire., Nicholson AN |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of clinical pharmacology [Br J Clin Pharmacol] 1974 Jun; Vol. 1 (3), pp. 209-15. |
| DOI: |
10.1111/j.1365-2125.1974.tb00238.x |
| Abstrakt: |
1 The residual effects of heptabarbitone given overnight were studied by an adaptive tracking technique. Decrements in performance were observed at the 10 h interval after 200 mg, at the 10 h and 13 h intervals after 300 mg and at the 10 h, 13 h, 16 h and 19 h intervals after 400 mg of the drug. Decrements in performance at each interval and the persistence of the effects were dose related. 2 Subjective assessments of performance correlated with measured performance, but the subjects, as a group, over-estimated their performance after placebo and heptabarbitone. With heptabarbitone (400 mg) highly significant decrements in performance persisted to the 19 h interval after ingestion, but subjective assessments of performance to the 19 h interval did not differ significantly from subjective assessments of control activity of the day before. 3 Individual blood concentrations of heptabarbitone did not give a significant correlation with individual performance decrements, though the blood concentrations and performance decrements at each dose were related. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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