| Autor: |
Aguiar GP; Núcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil., Melo NI, Wakabayashi KA, Lopes MH, Mantovani AL, Dias HJ, Fukui MJ, Keles LC, Rodrigues V, Groppo M, Silva-Filho AA, Cunha WR, Magalhães LG, Crotti AE |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product research [Nat Prod Res] 2013; Vol. 27 (10), pp. 920-4. Date of Electronic Publication: 2012 Mar 27. |
| DOI: |
10.1080/14786419.2012.671314 |
| Abstrakt: |
In this study, the chemical composition and the in vitro schistosomicidal properties of the essential oil obtained from Bidens sulphurea flowers (Bs-EO) were investigated. Its major constituents were identified as being 2,6-di-tert-butyl-4-methylphenol (44.98%), germacrene D (33.70%) and β-caryophyllene (10.23%). Bs-EO at 100 µg mL(-1) caused death of all the adult worms and promoted separation of the couple pairs into individual male and female within 48 h, besides leading to a significant decrease in the motility of the parasites. This oil was also responsible for a remarkable reduction in the number of eggs and the percentage of developed eggs produced by adult worms. These results suggest that the Bs-EO can be considered a promising source for the development of new schistosomicidal agents. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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