[Studying toxicity caused by interaction of caffeine and ketorolac].

Autor: Iudin MA, Kurpiakova AF, Bykov VN, Chepur SV, Nikiforov AS
Jazyk: ruština
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2012; Vol. 75 (1), pp. 27-9.
Abstrakt: Combined administration of caffeine and ketorolac (NSAID) is accompanied by all possible types of drug interaction. Side effects of the drug combination are mostly due to the action of ketorolac and manifested by decompensated renal failure and progressive endotoxemia within 3 - 7 days after single administration of drugs. Thus, the amplification of ketorolac effects by caffeine must be taken into consideration in prescribing NSAIDs.
Databáze: MEDLINE