Acral peeling skin syndrome in two East-African siblings: case report.

Autor: Kiprono SK; Department of Dermatology, Regional Dermatology Training Center at KCMC, Box 8332, Moshi, Tanzania. kipsam2@yahoo.com, Chaula BM, Naafs B, Masenga JE
Jazyk: angličtina
Zdroj: BMC dermatology [BMC Dermatol] 2012 Mar 19; Vol. 12, pp. 2. Date of Electronic Publication: 2012 Mar 19.
DOI: 10.1186/1471-5945-12-2
Abstrakt: Background: Acral peeling skin syndrome is a rare autosomal recessive genodermatosis due to a missense mutation in transglutaminase 5. The skin peeling occurs at the separation of the stratum corneum from the stratum granulosum.
Case Presentation: We present a case of two siblings who developed continuous peeling of the palms and soles from the first year of life. This peeling was more severe on the soles than palms and on younger sibling than elder sibling. Peeling is worsened by occlusion and sweating.
Conclusions: Sporadic cases of Acral Peeling Skin Syndrome occur in African population. There is variability in time of presentation and clinical severity even within families.
Databáze: MEDLINE
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