| Autor: |
Lago PM; Multidisciplinary Laboratory, Clementino Fraga Filho University Hospital, Institute of Thoracic Diseases, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil., Boéchat N, Migueis DP, Almeida AS, Lazzarini LC, Saldanha MM, Kritski AL, Ho JL, Lapa e Silva JR |
| Jazyk: |
angličtina |
| Zdroj: |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2012 May; Vol. 16 (5), pp. 656-9. Date of Electronic Publication: 2012 Mar 08. |
| DOI: |
10.5588/ijtld.11.0707 |
| Abstrakt: |
Interleukin (IL) 10 and interferon-gamma (IFN-) levels in induced sputum supernatants of 21 tuberculosis (TB) patients at diagnosis and during chemotherapy were correlated to recurrence rates. IL-10 decreased until day 60 of treatment (T60), and between T60 and T180 it increased again in 7 cases (Pattern 1) and further decreased in 14 cases (Pattern 2). Follow-up of 69 months was performed in 20/21 cases; 6 had recurrence of TB, of which 5/7 (71%) had Pattern 1 and 1/13 (7.7%) Pattern 2 (OR 30.0, 95%CI 2.19411.3, P 0.0072). This was not observed for IFN-. High IL-10 levels at the end of treatment may function as a risk factor for TB recurrence. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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