| Autor: |
Lee BY; Public Health Computational and Operations Research, University of Pittsburgh, Pennsylvania, 15213, USA. BYL1@pitt.edu, Bacon KM, Shah M, Kitchen SB, Connor DL, Slayton RB |
| Jazyk: |
angličtina |
| Zdroj: |
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2012 Mar; Vol. 86 (3), pp. 417-25. |
| DOI: |
10.4269/ajtmh.2012.10-0415 |
| Abstrakt: |
Visceral leishmaniasis (VL) is responsible for substantial morbidity and mortality and current available treatments have many limitations. The ability of VL infection to generate life-long immunity offers promise for the development of a VL vaccine. A VL vaccine candidate has recently completed phase I clinical trials. We constructed a computer simulation model to determine the potential economic value of a VL vaccine in the endemic region of Bihar state, India. Results found a potential vaccine to be cost-effective (and in many cases economically dominant, i.e., saving costs and providing health benefits) throughout a wide range of vaccination costs and vaccine efficacies, and VL risks. Overall, our study strongly supports the continued development of a VL vaccine. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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