| Autor: |
Vanderpas JB; Public Health School, Free University of Brussels, Belgium., Contempré B, Duale NL, Goossens W, Bebe N, Thorpe R, Ntambue K, Dumont J, Thilly CH, Diplock AT |
| Jazyk: |
angličtina |
| Zdroj: |
The American journal of clinical nutrition [Am J Clin Nutr] 1990 Dec; Vol. 52 (6), pp. 1087-93. |
| DOI: |
10.1093/ajcn/52.6.1087 |
| Abstrakt: |
Selenium status was determined in an endemic-goiter area and in a control area of Zaire. Compared with the reference values of a noniodine-deficient area, serum selenium in subjects living in the core of the northern Zaire endemic-goiter belt (Karawa villages) was seven times lower in 52 school-children and similarly low in 23 cretins; erythrocyte glutathione peroxidase (RBC-GPX) was five times lower in schoolchildren and still two times lower in cretins (P = 0.004). In a less severely iodine-deficient city of the same endemia (Businga), selenium status was moderately altered. RBC-GPX activity was linearly associated with serum selenium concentration up to a value of 1140 nmol/L and leveled off at approximately 15 U/g Hb at greater selenium concentration. At Karawa villages, selenium supplementation normalized both the serum selenium and the RBC-GPX. This combined iodine and selenium deficiency could be associated with the elevated frequency of endemic myxedematous cretinism in Central Africa. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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