| Autor: |
Kasturirangan V; Department of Radiation Medicine, and joint appointment in the Department of Cell Stress Biology, The NanoBiotechnology Center at Roswell Park Cancer Institute-NBC at RPCI, Buffalo, NY, USA., Nair BM, Kariapper MT, Lesniak WG, Tan W, Bizimungu R, Kanter P, Toth K, Buitrago S, Rustum YM, Hutson A, Balogh LP, Khan MK |
| Jazyk: |
angličtina |
| Zdroj: |
Nanotoxicology [Nanotoxicology] 2013 Jun; Vol. 7 (4), pp. 441-51. Date of Electronic Publication: 2012 Mar 20. |
| DOI: |
10.3109/17435390.2012.668570 |
| Abstrakt: |
Composite nanodevices (CNDs) are multifunctional nanomaterials with potential uses in cancer imaging and therapy. Poly(amidoamine) dendrimer-based composite nanodevices are important members of this group and consist of an organic dendrimer component and an incorporated inorganic component, in this case, gold. This study addresses the short- (14 days) and long-term (78 days) in vivo toxicity of generation-5 (G5; 5 nm) PAMAM dendrimer-based gold-CNDs (Au-CNDs) with varying surface charges (positive, negative and neutral) in C57BL/6J male mice. Detailed toxicological analyses of (1) body weight changes, (2) serum chemistry and (3) histopathological examination of 22 organs showed no evidence of organ injury or organ function compromise. Zeta potential of Au-CNDs showed significant change from their parent dendrimers upon gold incorporation, making the normally lethal positive surface dendrimer biologically safe. Also homeostatic mechanisms in vivo may compensate/repair toxic effects, something not seen with in vitro assays. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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