Influence of sealant fibrin on the wound healing of the pigs vocal folds.
| Autor: | Portes KP; Medical Science School, São Paulo Holy House-Santa Casa., Duprat Ade C, Lancellotti CL, Silva L, Souza FC |
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| Jazyk: | English; Portuguese |
| Zdroj: | Brazilian journal of otorhinolaryngology [Braz J Otorhinolaryngol] 2012 Feb; Vol. 78 (1), pp. 51-6. |
| DOI: | 10.1590/s1808-86942012000100008 |
| Abstrakt: | Unlabelled: Fibrin sealants or fibrin glue are products made from human plasma proteins, which mimic the final pathway of the coagulation cascade. Its application to stimulate the healing process has been a topic of debate in the literature. The use of fibrin sealants in phonosurgery has been empirical; there have been no studies that investigate the action of fibrin sealant in Reinke's space. Aim: To evaluate the effect of fibrin glue in healing of the vocal folds of pigs after surgical manipulation. Materials and Methods: This was a prospective and experimental study. Six animals had both vocal folds incised. Sealant was applied in one of them; the other served as a control. After three months, the animals were sacrificed and a collagen count was carried out. Results: The side on which glue was applied had an average of 27.8% against 20.4% of the side without glue. Conclusion: The collagen concentration in the samples where the fibrin sealant was applied was significantly higher compared to samples without glue. Thus, the presence of a fibrin sealant stimulates fibrogenesis in this tissue. |
| Databáze: | MEDLINE |
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