[Prenatal stressed female rats develop stable anxious and depressive state in experimental model of post-traumatic stress disorder].

Autor: Ordian NE, Pivina SG, Fedotova IuO, Rakitskaia VV
Jazyk: ruština
Zdroj: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova [Ross Fiziol Zh Im I M Sechenova] 2011 Nov; Vol. 97 (11), pp. 1187-95.
Abstrakt: The effects of immobilization stress from 15th to 19th days of gestation on pathological state development in the model of post-traumatic stress disorder in adult female offspring were studied. The results showed that prenatally stressed female rats as well as control rats demonstrated long-term high anxiety and hypersensitive glucocorticoid feedback in the stress-restress model. Enhanced depressive-like behaviour was found only in prenatally stressed females. The findings were discussed in the light of HPA axis alteration and risk factors for development of post-traumatic stress disorder.
Databáze: MEDLINE