Asparaginase-associated pancreatitis in a dog.

Autor: Schleis SE; Department of Clinical Sciences, College of Veterinary Medicine, Auburn University Hoerlein Hall, Auburn, Alabama 36849, USA. ses0034@auburn.edu, Rizzo SA, Phillips JC, LeBlanc AK
Jazyk: angličtina
Zdroj: The Canadian veterinary journal = La revue veterinaire canadienne [Can Vet J] 2011 Sep; Vol. 52 (9), pp. 1009-12.
Abstrakt: A dog with lymphosarcoma was evaluated for vomiting, lethargy, and abdominal pain 48 h after treatment with L-asparaginase. Based on drug administration, clinical signs, bloodwork, and elevated canine pancreatic lipase immunoreactivity, L-asparaginase-associated pancreatitis was diagnosed. This is an acknowledged toxicity; however, its pathophysiology and incidence rate in veterinary patients are unknown and sparsely documented.
Databáze: MEDLINE