| Autor: |
Hegazy MF; Chemistry of Medicinal Plants Department, and Center of Excellence for Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt., Eldeen AMG; Cancer Biology Lab, Center of Excellence for Advanced Sciences, and Biochemistry Department, National Research Center, Dokki Cairo 12622, Egypt., Shahat AA; Chemistry of Medicinal Plants Department, and Center of Excellence for Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt.; Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saudi University, PO Box 2457, Riyadh 11451, Saudi Arabia., Abdel-Latif FF; Department of Chemistry, Faculty of Science, Minia University, El-Minia 61519, Egypt., Mohamed TA; Chemistry of Medicinal Plants Department, and Center of Excellence for Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt., Whittlesey BR; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA., Paré PW; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA. |
| Abstrakt: |
A chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11(S) hydroperoxylsarcoph-12(20)-ene (1), and 12(S)-hydroperoxylsarcoph-10-ene (2), as well as 8-epi-sarcophinone (3). In addition to these three new compounds, two known structures were identified including: ent-sarcophine (4) and sarcophine (5). Structures were elucidated by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray diffraction. Isolated compounds were found to be inhibitors of cytochrome P₄₅₀ 1A activity as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity for these characterized metabolites. |
