Potent norovirus inhibitors based on the acyclic sulfamide scaffold.
| Autor: | Dou D; Department of Chemistry, Wichita State University, Wichita, KS 67260, USA., Tiew KC, Mandadapu SR, Gunnam MR, Alliston KR, Kim Y, Chang KO, Groutas WC |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Bioorganic & medicinal chemistry [Bioorg Med Chem] 2012 Mar 15; Vol. 20 (6), pp. 2111-8. Date of Electronic Publication: 2012 Feb 02. |
| DOI: | 10.1016/j.bmc.2012.01.030 |
| Abstrakt: | The development of small molecule therapeutics to combat norovirus infection is of considerable interest from a public health perspective because of the highly contagious nature of noroviruses. A series of amino acid-derived acyclic sulfamide-based norovirus inhibitors has been synthesized and evaluated using a cell-based replicon system. Several compounds were found to display potent anti-norovirus activity, low toxicity, and good aqueous solubility. These compounds are suitable for further optimization of pharmacological and ADMET properties. (Copyright © 2012 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect