The role of defects on the assembly and stability of DNA nanostructures.

Autor: Greene DG; Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA., Keum JW, Bermudez H
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2012 May 07; Vol. 8 (9), pp. 1320-5. Date of Electronic Publication: 2012 Feb 22.
DOI: 10.1002/smll.201102221
Abstrakt: Defects are known to underlie the mechanical properties of materials, especially so at the nanoscale. Using four compositionally identical DNA triangles, defect density is found to be inversely correlated with assembly efficiency and melting temperature. These findings are supported by a series of experiments with more complex DNA pyramids. Because they are naturally responsive to stresses, defects present an attractive opportunity as design elements for responsive DNA materials.
(Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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