[A comparative study of the efficacy of praziquantel and its liposomal form in experimental opisthorchiasis].

Autor: Strazhenskikh AN, Molokova OA, Chabanov MK, Bychkov VG, Iarotskiĭ LS
Jazyk: ruština
Zdroj: Meditsinskaia parazitologiia i parazitarnye bolezni [Med Parazitol (Mosk)] 1990 Jul-Aug (4), pp. 39-41.
Abstrakt: Intensive and extensive efficacy of praziquantel pure and that included in multilamellar liposomes was studied. As a result, a high anti-helminthic activity of liposomal praziquantel has been established. Negative effect of praziquantel on protein synthetic and enzymatic function of the liver has been revealed in normal animals. The treatment with liposomal praziquantel led to a rapid normalization of total lipid and bilirubin levels, thymol turbidity test, transaminase indices and also to a decrease in dystrophic liver changes.
Databáze: MEDLINE