| Autor: |
Hadjihannas MV; Nikolaus-Fiebiger-Center of Molecular Medicine, University of Erlangen, Glueckstrasse 6, 91054 Erlangen, Germany., Bernkopf DB, Brückner M, Behrens J |
| Jazyk: |
angličtina |
| Zdroj: |
EMBO reports [EMBO Rep] 2012 Apr; Vol. 13 (4), pp. 347-54. |
| DOI: |
10.1038/embor.2012.12 |
| Abstrakt: |
Wnt/β-catenin signalling regulates cell proliferation by modulating the cell cycle and is negatively regulated by conductin/axin2/axil. We show that conductin levels peak at G2/M followed by a rapid decline during return to G1. In line with this, Wnt/β-catenin target genes are low at G2/M and high at G1/S, and β-catenin phosphorylation oscillates during the cell cycle in a conductin-dependent manner. Conductin is degraded by the anaphase-promoting complex/cyclosome cofactor CDC20. Knockdown of CDC20 blocks Wnt signalling through conductin. CDC20-resistant conductin inhibits Wnt signalling and attenuates colony formation of colorectal cancer cells. We propose that CDC20-mediated degradation of conductin regulates Wnt/β-catenin signalling for maximal activity during G1/S. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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