| Autor: |
Clos AL; Department of Dermatology, MD Anderson Cancer Center, University of Texas Houston, TX, USA., Kayed R, Lasagna-Reeves CA |
| Jazyk: |
angličtina |
| Zdroj: |
Frontiers in neurology [Front Neurol] 2012 Jan 20; Vol. 3, pp. 5. Date of Electronic Publication: 2012 Jan 20 (Print Publication: 2012). |
| DOI: |
10.3389/fneur.2012.00005 |
| Abstrakt: |
Amyloidosis are a large group of conformational diseases characterized by abnormal protein folding and assembly which results in the accumulation of insoluble protein aggregates that may accumulate systemically or locally in certain organs or tissue. In local amyloidosis, amyloid deposits are restricted to a particular organ or tissue. Alzheimer's, Parkinson's disease, and amyotrophic lateral sclerosis are some examples of neurodegenerative amyloidosis. Local manifestation of protein aggregation in the skin has also been reported. Brain and skin are highly connected at a physiological and pathological level. Recently several studies demonstrated a strong connection between brain and skin in different amyloid diseases. In the present review, we discuss the relevance of the "brain-skin connection" in different neurodegenerative amyloidosis, not only at the pathological level, but also as a strategy for the treatment of these diseases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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