The prevalence of non-alcoholic fatty liver disease and metabolic syndrome in obese children.
| Autor: | Gupta R; Division of Pediatric Endocrinology, Infant's,Children Hospital of Brooklyn at Maimonides Brooklyn, New York, NY 11219, USA., Bhangoo A, Matthews NA, Anhalt H, Matta Y, Lamichhane B, Malik S, Narwal S, Wetzler G, Ten S |
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| Jazyk: | angličtina |
| Zdroj: | Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2011; Vol. 24 (11-12), pp. 907-11. |
| DOI: | 10.1515/jpem.2011.282 |
| Abstrakt: | Background and Aim: In the context of present epidemic of childhood obesity, we aimed to find the prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) in a cohort of obese children. Methodology: Retrospective chart analysis of 700 obese children was done for their anthropometric and biochemical investigations. Results: Some 15.4% (9.8% girls, 22% boys) subjects had NAFLD (ALT > 40 IU/L) after excluding other identifiable causes of liver dysfunction. Age, weight, TG, fasting serum insulin and HOMA-IR levels were higher in children with NAFLD. Twenty-eight percent children had MS. Children with NAFLD had an odds ratio of 2.65 for having MS (boys 4.6, girls 1.7). The prevalence of MS increased with age 5-9 years (21%), 10-16 years (30%), 17-20 years (35%). Conclusion: Given high prevalence of NAFLD and MS in obese children, childhood obesity should be seriously considered as a disease and not just a cosmetic issue. |
| Databáze: | MEDLINE |
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