Occupational exposures among nurses and risk of spontaneous abortion.

Autor: Lawson CC; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA. clawson@cdc.gov, Rocheleau CM, Whelan EA, Lividoti Hibert EN, Grajewski B, Spiegelman D, Rich-Edwards JW
Jazyk: angličtina
Zdroj: American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2012 Apr; Vol. 206 (4), pp. 327.e1-8. Date of Electronic Publication: 2011 Dec 30.
DOI: 10.1016/j.ajog.2011.12.030
Abstrakt: Objective: We investigated self-reported occupational exposure to antineoplastic drugs, anesthetic gases, antiviral drugs, sterilizing agents (disinfectants), and X-rays and the risk of spontaneous abortion in US nurses.
Study Design: Pregnancy outcome and occupational exposures were collected retrospectively from 8461 participants of the Nurses' Health Study II. Of these, 7482 were eligible for analysis using logistic regression.
Results: Participants reported 6707 live births, and 775 (10%) spontaneous abortions (<20 weeks). After adjusting for age, parity, shift work, and hours worked, antineoplastic drug exposure was associated with a 2-fold increased risk of spontaneous abortion, particularly with early spontaneous abortion before the 12th week, and 3.5-fold increased risk among nulliparous women. Exposure to sterilizing agents was associated with a 2-fold increased risk of late spontaneous abortion (12-20 weeks), but not with early spontaneous abortion.
Conclusion: This study suggests that certain occupational exposures common to nurses are related to risks of spontaneous abortion.
(Published by Mosby, Inc.)
Databáze: MEDLINE
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