| Autor: |
Zhang H; Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, China., Zhang L, Peng LJ, Dong XW, Wu D, Wu VC, Feng FQ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of Zhejiang University. Science. B [J Zhejiang Univ Sci B] 2012 Feb; Vol. 13 (2), pp. 83-93. |
| DOI: |
10.1631/jzus.B1100049 |
| Abstrakt: |
Fatty acids and derivatives (FADs) are resources for natural antimicrobials. In order to screen for additional potent antimicrobial agents, the antimicrobial activities of FADs against Staphylococcus aureus were examined using a microplate assay. Monoglycerides of fatty acids were the most potent class of fatty acids, among which monotridecanoin possessed the most potent antimicrobial activity. The conventional quantitative structure-activity relationship (QSAR) and comparative molecular field analysis (CoMFA) were performed to establish two statistically reliable models (conventional QSAR: R(2)=0.942, Q(2)(LOO)=0.910; CoMFA: R(2)=0.979, Q(2)=0.588, respectively). Improved forecasting can be achieved by the combination of these two models that provide a good insight into the structure-activity relationships of the FADs and that may be useful to design new FADs as antimicrobial agents. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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