A review of the association between osteosarcoma metastasis and protein translation.

Autor: Osborne TS; Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Khanna C
Jazyk: angličtina
Zdroj: Journal of comparative pathology [J Comp Pathol] 2012 Feb-Apr; Vol. 146 (2-3), pp. 132-42. Date of Electronic Publication: 2012 Jan 31.
DOI: 10.1016/j.jcpa.2011.12.007
Abstrakt: The malignant transformation of mesenchymal cells within the bone leads to the development of osteosarcoma (OS), but the genetic underpinnings of these events are not understood. From a clinical perspective, primary tumour management can be achieved successfully in most patients. However, the development of metastasis to the lungs represents the most common cause of death in OS patients. A clearer understanding of metastasis biology is required to improve cancer mortality and improve outcomes. Modelling the genetics, biology and therapy of OS can be accomplished through research involving a number of species. Most notable is the naturally occurring form of OS that develops in dogs. Through a cross-species and comparative approach important questions can be asked within specific and suitable models to advance our understanding of this disease and its common metastatic outcome. A comparative perspective on the problem of OS metastasis that utilizes a cross-species approach may offer unique opportunities to assist in this prioritization and generate new hypotheses related to this important clinical problem.
(Copyright © 2011 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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