Urinary estrogen metabolites during a randomized soy trial.

Autor: Morimoto Y; University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA., Conroy SM, Pagano IS, Isaki M, Franke AA, Nordt FJ, Maskarinec G
Jazyk: angličtina
Zdroj: Nutrition and cancer [Nutr Cancer] 2012; Vol. 64 (2), pp. 307-14. Date of Electronic Publication: 2012 Jan 31.
DOI: 10.1080/01635581.2012.648819
Abstrakt: One of the hypothesized protective mechanisms of soy against breast cancer involves changes in estrogen metabolism to 2-hydroxy (OH) and 16α-OH estrogens. The current analysis examined the effect of soy foods on the 2:16α-OH E(1) ratio among premenopausal women during a randomized, crossover intervention study; women were stratified by equol producer status, a characteristic thought to enhance the protective effects of soy isoflavones. The study consisted of a high-soy diet with 2 soy food servings/day and a low-soy diet with <3 servings of soy/wk for 6 mo each; estrogen metabolites were measured in 3 overnight urines (baseline and at the end of the low- and high-soy diet) using gas chromatography mass spectrometry for the 82 women who completed the study. Urinary isoflavonoids were assessed by liquid chromatography mass spectrometry. When applying mixed models, the 2:16α-OH E(1) ratio increased (P = 0.05) because of a nonsignificant decrease in 16α-OH E(1) (P = 0.21) at the end of the high-soy diet. Similar nonsignificant increases in the 2:16α-OH E(1) ratio were observed in equol producers (P = 0.13) and nonproducers (P = 0.23). These findings suggest a beneficial influence of soy foods on estrogen metabolism regardless of equol producer status.
Databáze: MEDLINE
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