| Autor: |
Santos RF; Laboratório de Tecnologia Farmacêutica Prof. Delby Fernandes de Medeiros, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil., Martins IR, Monteiro Fde S, Travassos Rde A, Janebro DI, Tavares JF, Silva MS, da Silva BA |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product research [Nat Prod Res] 2012; Vol. 26 (24), pp. 2335-9. Date of Electronic Publication: 2012 Jan 31. |
| DOI: |
10.1080/14786419.2011.653974 |
| Abstrakt: |
We aimed to investigate the possible spasmolytic activity of ent-7α-acetoxytrachyloban-18-oic acid (1) and ent-7α-hydroxytrachyloban-18-oic acid (2) on smooth muscle models. In male rat aorta and rat uterus, both diterpenes were unable to trigger spasmolytic action. However, 2 relaxed guinea-pig trachea: Compounds 1 and 2 antagonised, significantly and concentration-dependently, carbachol- and histamine-induced phasic contractions in guinea-pig ileum. Moreover, they induced a significant and concentration-dependent relaxation in pre-contracted (KCl, carbachol or histamine) guinea-pig ileum, with 2 being 15 times more potent than 1 in histamine-contracted ileum. These dissimilar results may be due to chemical differences between them. Thus, we demonstrated that 1 and 2 seem to be promising spasmolytic agents, although further studies are required to elucidate the spasmolytic action mechanism. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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