| Autor: |
de Oliveira CB; Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. cristiane_gabi@yahoo.com.br, Comunello LN, Lunardelli A, Amaral RH, Pires MG, da Silva GL, Manfredini V, Vargas CR, Gnoatto SC, de Oliveira JR, Gosmann G |
| Jazyk: |
angličtina |
| Zdroj: |
Molecules (Basel, Switzerland) [Molecules] 2012 Jan 23; Vol. 17 (1), pp. 1113-23. Date of Electronic Publication: 2012 Jan 23. |
| DOI: |
10.3390/molecules17011113 |
| Abstrakt: |
Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg/kg decreased significantly the analyzed parameters when compared to the carrageenan group ( p < 0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity ( p < 0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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