Multiplexed microneedle-based biosensor array for characterization of metabolic acidosis.
| Autor: | Miller PR; Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Raleigh, NC 27695-7115, USA., Skoog SA, Edwards TL, Lopez DM, Wheeler DR, Arango DC, Xiao X, Brozik SM, Wang J, Polsky R, Narayan RJ |
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| Jazyk: | angličtina |
| Zdroj: | Talanta [Talanta] 2012 Jan 15; Vol. 88, pp. 739-42. Date of Electronic Publication: 2011 Nov 22. |
| DOI: | 10.1016/j.talanta.2011.11.046 |
| Abstrakt: | The development of a microneedle-based biosensor array for multiplexed in situ detection of exercise-induced metabolic acidosis, tumor microenvironment, and other variations in tissue chemistry is described. Simultaneous and selective amperometric detection of pH, glucose, and lactate over a range of physiologically relevant concentrations in complex media is demonstrated. Furthermore, materials modified with a cell-resistant (Lipidure(®)) coating were shown to inhibit macrophage adhesion; no signs of coating delamination were noted over a 48-h period. (Copyright © 2011 Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
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