[The induction of tolerance in mice for a human melanoma graft].

Autor: Bogush TA, Lokshin A, Smirnova GB, Iushkov SF, Karpov IA, Ovumian GSh, Kastrykina VN, Chimishkian KL
Jazyk: ruština
Zdroj: Eksperimental'naia onkologiia [Eksp Onkol] 1990; Vol. 12 (5), pp. 59-62.
Abstrakt: Mouse skin allografts and intramuscular BRO human melanoma xenografts were successfully established in phenotypically normal mice after inducing immunological tolerance in the recipients. Tolerance was achieved by inoculating allogenic embryonic liver cells after the whole-body irradiation. No immunological rejection was evident in BRO xenografts for 34 days after transplantation. During this period the BRO cells invaded neighboring tissues and formed distant micrometastases in the lungs.
Databáze: MEDLINE