Histologic inflammatory changes on the prostatic gland due to immunosuppression for kidney transplantation.

Autor: Piovesan AC; Renal Transplantation Unit, Division of Urology, University of São Paulo Medical School, São Paulo, São Paulo, Brazil., Torricelli FC, Antonopoulos IM, Falci R Jr, Kanashiro H, Nahas WC
Jazyk: angličtina
Zdroj: Urology [Urology] 2012 Mar; Vol. 79 (3), pp. 662-4. Date of Electronic Publication: 2012 Jan 13.
DOI: 10.1016/j.urology.2011.11.006
Abstrakt: Objective: To determine the incidence of type IV prostatitis in patients with kidney transplantation receiving an immunosuppression regimen and to compare it with that of a nonimmunosuppressed control group.
Methods: We retrospectively reviewed 216 electronic charts of patients who had undergone surgical treatment for benign prostatic hyperplasia from August 2000 to January 2006. Of the 216 patients, 183 did not receive immunosuppressive therapy and were included in the control group (group 1). The other 33 patients had undergone kidney transplantation and were included in the study group (group 2). The patient data were accessed for age at surgery, International Prostate Symptom Score, prostate volume, preoperative serum prostate-specific antigen level, history of acute urinary retention, and surgical approach (open vs transurethral resection of prostate). Histologic findings from the surgical specimens were also recorded.
Results: The mean age at surgery, mean serum prostate-specific antigen level, mean prostate volume, and mean International Prostate Symptom Score were not significantly different between both groups. However, histologic evidence of chronic prostatitis was obtained in 145 surgical specimens (78%) from group 1 and in just 3 specimens from group 2 (9%; P < .001). Moreover, nonimmunosuppressed patients had a 38.2 times greater risk of presenting with prostatitis than did the immunosuppressed patients.
Conclusion: Immunosuppression therapy in kidney transplantation has a protective factor in the prostatitis incidence.
(Copyright © 2012 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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