Prescription for antiresorptive therapy in Mexican patients with rheumatoid arthritis: is it time to reevaluate the strategies for osteoporosis prevention?

Autor: Gamez-Nava JI; Unidad de Investigación en Epidemiología Clínica, Instituto Mexicano del Seguro Social (IMSS) Hospital de Especialidades Centro Médico Nacional de Occidente, Guadalajara, Mexico., Zavaleta-Muñiz SA, Vazquez-Villegas ML, Vega-Lopez A, Rodriguez-Jimenez NA, Olivas-Flores EM, Gonzalez-Montoya NG, Corona-Sanchez EG, Rocha-Muñoz AD, Martinez-Corral ME, Martin-Márquez BT, Vazquez-Del Mercado M, Muñoz-Valle JF, Cardona-Muñoz EG, Celis-De La Rosa A, Cabrera-Pivaral C, Gonzalez-Lopez L
Jazyk: angličtina
Zdroj: Rheumatology international [Rheumatol Int] 2013 Jan; Vol. 33 (1), pp. 145-50. Date of Electronic Publication: 2012 Jan 12.
DOI: 10.1007/s00296-011-2341-9
Abstrakt: Glucocorticoids are frequently used in rheumatoid arthritis (RA) in order to alleviate symptoms of joint inflammation, retard erosions and to treat extra-articular manifestations, although these drugs may increase the risk of bone mineral loss and osteoporotic fractures. To date, in Mexico there are no studies that identify the frequency of patients with RA with corticosteroids, receiving therapy for osteoporosis. Therefore, we evaluated the prevalence and factors related to the prescription of antiresorptives in 520 Mexican patients with RA. We used a multivariate model to identify variables associated with antiresorptives prescription. We identified that although 79% of patients were under treatment with glucocorticoids, only 13% received antiresorptive agents as preventive therapy for osteoporosis. The multivariate analysis identified that higher proportions of antiresorptive drugs prescriptions were associated with female patients (OR 11.40, 95% CI: 1.5-84.3, P = 0.02), an age of 40 years or more (OR 3.22, 95% CI: 1.3-8.3, P = 0.02) and to consume a lower number of cointerventions with other drugs (OR 1.09, 95% CI: 1.0-1.2, P = 0.03). Corticosteroid treatment was not associated with the prescription of antiresorptives (P = 0.31). In conclusion, a low proportion of Mexicans with RA receive antiresorptive therapy independently regardless of whether they consume or not chronically corticosteroids. Additional strategies should be evaluated to encourage the prevention and early treatment for osteoporosis in patients with RA.
Databáze: MEDLINE
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