| Autor: |
Shipaeva EV; V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia., Kovalenko LP, Sorokina AV, Kovalev GI, Tallerova AV, Kolik LG, Gudasheva TA, Durnev AD, Seredenin SB |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2011 Mar; Vol. 150 (5), pp. 599-602. |
| DOI: |
10.1007/s10517-011-1200-8 |
| Abstrakt: |
Anti-inflammatory effects of GB-115 compound (N-phenylhexanoyl-glycyl-L-tryptophan amide) injected intraperitoneally in doses of 0.1, 1, and 10 mg/kg were demonstrated on the model of ConA- and carrageenan-induced inflammation. Intraperitoneal injection of GB-115 in a dose of 1 mg/kg to C57Bl/6 female mice with experimental autoimmune encephalomyelitis significantly alleviated the pathological symptoms, improved spontaneous locomotor activity, promoted recovery of thymus weight, and reduced edema and neutrophil infiltration of the perivascular space of the brain tissue. Intraperitoneal injection of GB-115 in a dose of 1 mg/kg suppressed generation of active oxygen forms by neutrophils in the chemiluminescence test. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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